Sathrughnan

Nandagopal (Mammootty), a high-ranking & rich IAS officer, pampers & raises his epileptic sister Ammu, resulting in her being short-tempered & spoilt. Nandan marries Gauri (Shobana) on condition that Gauri's younger brother Venu (Dileep) marries Ammu, without disclosing Ammu's condition. Although Venu learns of it, it was too late. After the marriage, Ammu finds it tough to adjust to Venu's environment, complicated by the fact that Nandan still catered to Ammu's whims & continued to pamper her.

Best friends Eby (Kunchako Boban) & Sona (Shalini) were born on the same day, grew up together, are neighbors & goes to the same college. After they had to stay apart for a week for the first time, Eby develops feelings of love towards Sona, but stifles them, afraid of Sona's response & also because Sona had responded to overtures from college mate Prakash Mathew (Boban Alumoodan). However, when Sona realizes that marrying Prakash means leaving Eby, she also realizes her love towards Eby.

Sunil (Kunchako Boban), a christian, & Hema (Shalini), a Hindu, both orphans, fall in love & get married without knowing that their partner also was an orphan. After they are forced to come up with their parents to save their faces amongst their neighbors, they "adopt" an elderly couple, Menon (Thilakan) & Sreedevi (Bharathi), from a retirement home. Just as Sunil & Hema warm up to their new-found parents, the elderly couples' real son, Jayan (Saikumar), comes calling, claiming ownership.

Gopi (Dileep) falls in love with his neighbor Anjali (Manju Warrier), & Anjali reciprocates, but later decides to sacrifice her love because of her still unmarried elder sisters, mute Ashwathy (Mohini) & Aarti (Chippy). Learning of her reasoning, Gopi takes it upon himself to get Ashwathy & Aarti married off, so that he & Anjali could marry. However, the sisters' abusive half-brother Raghu (Meghanadhan) poses a threat to Gopi's plans.

Dr. Ravi Varman (Suresh Gopi), a brilliant but eccentric shrink who only treats one patient at a time, takes up the case of Yamuna (Navya Nair), an acutely schizophrenic girl & cures her, but in the process messes up his own marriage to Jyothi (Shweta Menon). 3 years later, just days to go before Yamuna's wedding, she receives a letter from Unni Nedungadi (Jagathi Sreekumar), Ravi's manservant, with the message that Ravi wishes to see her urgently.

Nandakumar (Mukesh) & Shashankan (Harisree Asokan), after various failed odd jobs, opens an Ayurvedic clinic, armed with knowledge gained from the medical texts of Nandakumar's long-gone father Vasudeva Panicker (Narendra Prasad), who was a great Ayurvedic doctor during his time. A pharmaceutical company approaches Nandakumar with a research job offer to find a cure for asthma, & Nandakumar takes up the challenge, knowing well that the company was the reason his father disappeared in disgrace.

Famed singer Subadra Thampuratti (Srividya) & her estranged husband R.K. Nair (Thilakan) have been in a custody battle over their daughters Sangeetha (Rasika) & Manasi (Sneha). Nair hires a street artist Charlie (Kunchacko Boban) to infiltrate Subadra's household as a music pupil to have an inside man there. Contrary to Nair's plans though, Charlie & Manasi fall in love. Pining for Charlie outside was his childhood friend, the blind Uma (Sujitha), for whose treatment he had agreed to this act.

Melina (Malavika Wales), a French citizen of Indian heritage, comes to Kerala to find the whereabouts of her Malayali father, Unnikrishnan (Vineeth). Years ago, Unnikrishnan had had a romantic affair with her mother Romi Michel (Irina Jacobi), a French lady who had come to the Kalamandalam dance school in Cheruthuruthy, Kerala to learn Kathakali.