Mitsuko Kase

Every weapon must have a prototype. For the ultimate weapon, career soldier Lt. Mizuki is that prototype. As she comes to the limit of her powers as a weapon, she must watch the unfolding of Chise's growth into the final weapon. (imdb)

Shuuji and Chise are third year students at a high school in Hokkaido. The shy Chise is finally confessing to Shuuji, and finally the two of them are starting to exchange diary awkwardly. One day, Shuuji tries to escape from a sudden enemy air raid on Sapporo. While desperately escaping from the air raid, Shuuji sees a scene that he could not forget for his life. He sees Chise, with a huge weapon looking as if it was part of her hand, shooting the enemy fighters down one by one. (myanimelist.net)

Kuroo Hazama, an aspiring young medical student, studies diligently from Dr. Jôtarô Honma, a top surgeon who had saved Hazama's life when boy Hazama was badly injured by an unexploded bomb. Someday in the future, Hazama will be known as "Black Jack," a surgeon with unsurpassed skills but without a license. (animenewsnetwork)